Is it possible you can become resistant to Rifaximin? And if you or your child is on continuous should you take a break after a period of continuous use?

The development of long-term bacterial resistance to rifaximin is extremely rare even with continuous, daily dosing over a year or more.  Although bacterial resistance to rifaximin occurs very rarely, the resistance quickly disappears after discontinuing rifaximin for only a few weeks. The rifaximin can then be restarted with the same positive effect.