Question 1

Are primed-microglia permanent?

Accepted Answer

The use of vagus nerve stimulation, high concentrations of the omega-3 fatty acid DHA, and extra virgin olive oil have been shown in animal models to cause primed M1-microglia to shift their behavior into an anti-inflammatory, tissue-repairing M2-microglia.  These will need to be continued long term until other methods of eliminating primed microglia are found.

Question 2

Are primed-microglia permanent?

Accepted Answer

The use of vagus nerve stimulation, high concentrations of the omega-3 fatty acid DHA, and extra virgin olive oil have been shown in animal models to cause primed M1-microglia to shift their behavior into an anti-inflammatory, tissue-repairing M2-microglia.  These will need to be continued long term until other methods of eliminating primed microglia are found.